Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.
Grimbacher B; Hutloff A; Schlesier M; Glocker E; Warnatz K; Dräger R; Eibel H; Fischer B; Schäffer AA; Mages HW; Kroczek RA; Peter HH; Nature Immunology, 2003, vol. 4, issue 3, p 261, ISSN 15292908. ISBN 15292908.

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