The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.
Netter MF; Zuzarte M; Schlichthörl G; Klöcker N; Decher N; Cellular Physiology And Biochemistry: International Journal Of Experimental Cellular Physiology, Biochemistry, And Pharmacology, 2012, vol. 30, issue 5, p 1227, ISSN 14219778. ISBN 14219778.

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