Argonaute2 is the catalytic engine of mammalian RNAi.
Liu J; Carmell MA; Rivas FV; Marsden CG; Thomson JM; Song JJ; Hammond SM; Joshua-Tor L; Hannon GJ; Science (New York, N.Y.), 2004, vol. 305, issue 5689, p 1437, ISSN 10959203. ISBN 10959203.

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