ICOS co-stimulatory receptor is essential for T-cell activation and function.
Chen Dong; Juedes, Amy E.; Temann, Ulla-Angela; Shresta, Sujan; Allison, James P.; Ruddle, Nancy H.; Flavell, Richard A.; Nature, 2001, vol. 409, issue 6816, p 97, ISSN 00280836. ISBN 00280836.

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