Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
De Rooij, Johan; Zwartkruis, Fried J.T.; Verheijen, Mark H. G.; Cool, Robbert H.; Nijman, Sebastian M. B.; Wittinghofer, Alfred; Bos, Johannes L.; Nature, 1998, vol. 396, issue 6710, p 474, ISSN 00280836. ISBN 00280836.

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