We found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitleCompensating enthalpic and entropic changes hinder binding affinity optimization.AuthorsLafont V; Armstrong AA; Ohtaka H; Kiso Y; Mario Amzel L; Freire EPublicationChemical biology & drug design, 2007, Vol 69, Issue 6, p413ISSN1747-0277Publication typearticleDOI10.1111/j.1747-0285.2007.00519.x