We found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitleLoss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.AuthorsZhang H; Cicchetti G; Onda H; Koon HB; Asrican K; Bajraszewski N; Vazquez F; Carpenter CL; Kwiatkowski DJPublicationThe Journal of clinical investigation, 2003, Vol 112, Issue 8, p1223ISSN0021-9738Publication typearticleDOI10.1172/JCI17222