We found a matchYour institution may have access to this item. Find your institution then sign in to continue.TitlePlacebo-controlled trials and active-control trials in the evaluation of new treatments. Part 1: ethical and scientific issues.AuthorsTemple R; Ellenberg SSPublicationAnnals of internal medicine, 2000, Vol 133, Issue 6, p455ISSN0003-4819Publication typearticleDOI10.7326/0003-4819-133-6-200009190-00014